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10.1016/j.bbrc.2004.09.220 Biochem Biophys Res Commun

In Europe, the semaglutide compound benefits from Supplementary Protection Certificates (SPCs), extending protection until March 2031

Exenatide has been recently shown to reduce cerebrospinal fluid (CSF) secretion and ICP [16]

And small peptide GLP-1 analogues have been demonstrated to cross BBB via peripheral administration, including LG, lixisenatide and exendin-4 ( Analyzing cerebrospinal fluid (CSF), ventricular fluid (VF), and postmortem brain tissue by means of multiplex bead-based ELISAs, the results of the experiment further suggested that there are fifteen cytokines whose levels are elevated in CSF and brain in the course of early-stage AD ( Box 2 , suggesting that GLP-1 suppresses inflammatory responses by inhibiting the MAPKs signaling pathway ( Figure 2

(PubMed) Wang Y, Li X, Guo Y, Chan L, Guan X