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GLP-1 drugs may be prescribed for the following conditions as per American Diabetes Association/European Association for the Study of Diabetes (ADA/EASD) 2025 guidelines 11 : Primary glycaemic indication: GLP-1 RAs are recommended for adults with type 2 diabetes who have not reached their individualised A1C targets (typically when A1C is 1.5% above the agreed glycaemic goal) despite lifestyle measures and foundational therapy such as metformin

Mounjaro's primary purpose is glycaemic control, and this should remain the focus of your monitoring HbA1c measurements : Your GP or diabetes nurse will check your HbA1c (a measure of average blood glucose over 2-3 months) at regular intervals, typically every 3-6 months, to assess diabetes control Kidney function : Both diabetes and certain supplements can affect kidney function

- Anakinra, Canakinuma: IL-1 pathway - Tocilizumab, Ziltivekimab: IL-6 pathway - Methotrexate, corticosteroids: pleiotrophic modulators of inflammation, etc

When this selection profile is used, melanogenesis is more focused, and it has fewer unwanted effects on pathways that control hunger and sexual function

If nausea is severe or persistent, inform your prescriber about slowing your titration schedule