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The supernatant of tumor cells treated with Ru(II)-OH, NP2, and NP4 was co-cultured with RAW264.7 macrophages, and the intracellular calcium levels in macrophages were evaluated (Fig

GHK-Cu stimulates the proliferation of follicular keratinocytes , effectively "enlarging" the follicle base

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Dev Comp Immunol 15(12):3339

These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time