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McCluskey D, Touger MS, Melis R, et al

Their use for Alcohol Use Disorder (AUD) or drug addiction is considered "off-label." However, groundbreaking clinical research from 2025 and 2026 demonstrates that these medications significantly dampen the brain's reward centers, drastically curbing cravings for alcohol, opioids, and nicotine

During the mid-cycle, when ovulation occurs and estrogen peaks, a significant increase in the occurrence of wheal and flare is observed due to histamine (ref)