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Recent studies have validated this general approach demonstrating that molecules designed around angiotensin IV or the hinge sequence itself can bind HGF, block its dimerization, and attenuate HGF-dependent cellular actions
The diversity of extracellular vesicles (EVs) (338, 339) and the minimal uniformity regarding the methodologies for their isolation, purification, and characterization (340) make the application of EVs in the clinical setting challenging
In the New England Journal of Medicine, Garvey and colleagues [5] report the results of the REDEFINE 1 trial, a 68-week, phase 3a double-blind, placebo-controlled and active-controlled trial evaluating the efficacy and safety of coadministered cagrilintide and semaglutide in adults with obesity [body mass index (BMI) 30 kg/m 2 ] or overweight (BMI 27 kg/m 2 ) with at least one weight-related comorbidity
Table S1)
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