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Collectively, these sequences share a conserved metal binding site conforming to a DxHx 10 Hx 2 (H/E) motif in the 5 helix that defines an interfacial site between the two subunits of the dimer, and an additional metal binding site harboring a CxC motif in the 3 helix (Figure 10B)

Do it incorrectly, and you can damage the fragile peptide chains

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GLP-1 receptor agonists stimulate glucose-dependent insulin secretion and suppress appetite, whilst metformin reduces hepatic glucose production and enhances insulin sensitivity