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Moreover, since disturbance of these systems functions (i.e

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examined the susceptibility of different monocyte subsets to H 2 O 2 -induced cytotoxicity, and reported that CD16 + monocytes had increased cell death in response to H 2 O 2 as well as decreased GPx1 expression [46] (knockdown of GPx1 in CD16 monocytes recapitulated the phenotype)

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After the size of subcutaneous DR-B16F10 melanoma reached about 100 mm 3 , the tumor-bearing mice were randomized and treated with various therapeutics every other day three times in total (Fig