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Retatrutide + MOTS-c Clinical Evidence Context Direct stack evidence No published human or animal trial has tested retatrutide + MOTS-c together

doi: 10.3389/fendo.2023.1098032 14 ThongKYGuptaPSBlannADRyderREJ

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In this section we review the structure-activity relationship behind the various half-life extending strategies in the context of GLP-1 RA development and, in turn, how these modifications impact pharmacokinetic parameters and dosing scheduling of the resulting GLP-1 RA products