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Many patients notice improvements in fasting glucose and insulin levels within 48 weeks of starting semaglutide, before substantial weight loss occurs

[20] Your provider may keep you on that cadence for several weeks before tapering or discontinuing as goals are met

Medications that slow down digestion: Semaglutide already slows gastric emptying, so combining it with other medications that have this effect (such as opioids ) could worsen gastrointestinal side effects like nausea, vomiting, or bloating

Joint pain often decreases as the stress on knees, hips, and back is reduced

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