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Cost is a common issue too, since staying on the medication long term is often necessary to hold onto results, and that adds up fast without solid insurance coverage

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While initial clinical observations indicate promising effects in specific conditions such as diabetic peripheral neuropathy, irritable bowel syndrome, and idiopathic intracranial hypertension, rigorous clinical trials are needed to confirm their efficacy, elucidate weight-loss-independent mechanisms, and establish comprehensive safety profiles across various pain conditions

2022 [cited 2022 Apr 7];134

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