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Abbreviations ASCVD: Atherosclerotic cardiovascular disease ATE: Average treatment effect BMI: Body mass index CI: Confidence interval CKD: Chronic kidney disease CV: Cardiovascular eGFR: Estimated glomerular filtration rate GIP: Glucose-dependent insulinotropic polypeptide GLP-1RA: Glucagonlike peptide-1 receptor agonist HBA 1c : Glycated hemoglobin HR: Hazard ratio ICD-10-CM: International Classification of Diseases, Tenth Revision, Clinical Modification MACE: Major adverse cardiovascular event MI: Myocardial infarction OW: Once weekly PY: Person-years RCTs: Randomized controlled trials SGLT2i: Sodium-glucose cotransporter 2 inhibitor SMDs: Standardized mean differences T2D: Type 2 diabetes References Fonseca VA

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(2025) 188:412429.e27

Increasing dose while under-eating protein or sleeping 5 hours is like adding gas to a car with flat tires

Compounded medications are not themselves FDA-approved but are legal, regulated, and made to pharmaceutical standards for personalized patient use