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Its extensive distribution and involvement in diverse physiological processes emphasize the important role of GLP-1R beyond the regulation of glucose metabolism.38,39,40 The phenotype observed after GLP-1R knockout (KO) includes various physiological and metabolic changes

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Studies show combination therapy produces greater HbA1c reductions and weight loss than either agent alone in many patients

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doi: 10.1074/jbc.274.52.37491

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