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These observations suggest the critical roles of estrogen in normal metabolism function for glucose metabolism and energy homeostasis and that estrogen-deprivation induced systemic inflammation which is associated with increased glycolysis, increased lactate production and reduced TCA cycle activity and these effects were revered upon estrogen supplementation

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Last Published 11.01.2025 Effective Date: 11.01.2025 This policy addresses the use of Krystexxa (pegloticase) for treatment of chronic gout refractory to conventional therapy

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