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However, only a small amount of metformin was transported through the outer basement membrane of the small intestinal epithelial cells into the bloodstream, resulting in metformin accumulation in these cells (Proctor et al., 2008)

However, it should be noted as mentioned previously, in conditions where it does not increase glucose oxidation, carnitine supplementation worsens both injury and recovery of contractile function after transient ischemia in the perfused rat heart [122]

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(7) Centrifuge for 10 min (12000 rpm, 4C), 150 L of supernatant was loaded into an LC-MS injection vial with a liner tube for LC-MS analysis