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Conversely, if GLP-1-related blunting is selective to reward-related content, these compounds may normalize aberrant hyperreactivity in individuals with obesity or substance use disorders without reducing negative affective processing

In the UK, topiramate is licensed for: Epilepsy as monotherapy in adults and children aged 6 years and over, and as adjunctive treatment in adults and children aged 2 years and over for focal seizures, generalised tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome Migraine prevention as prophylactic treatment in adults only, when other options have been insufficient or are not tolerated

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In humans, most studies do not show a positive effect on the weight reduction facilitated by L-carnitine

Reduced Saliva Production Chapped lips can occur when the body produces less saliva than normal, leading to dry mouth or xerostomia