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Glutathione - Safety A clinical trial showed that daily oral glutathione supplementation effectively increased its levels in oral buccal cells and various intra- and extracellular blood compartments, showing that long-term supplementation is responsible for increased blood glutathione levels (4, 6)

Hence, glutathione treatment reduces melanin production by the body, which lightens the skin

Nozaki T, Asai T, Sanchez LB, Kobayashi S, Nakazawa M, and Takeuchi T

It converts 5,10-methylenetetrahydrofolate (MeTHF) to 5-methyltetrahydrofolate (MTHF) as part of the one-carbon pathway

The pentadecapeptide is stable in stomach acid, which is why oral routes are also studied in addition to subcutaneous