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Thats normal, and usually, a bit of rest sorts it out

The patients were advised to maintain usual habits and to avoid physically intense/vigorous exercise, smoking, or substantial changes in regular diet the day before the examination

That dual role is exactly why its worth understanding rather than labeling good or bad

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Also, despite the use of randomized trial designs and blind assessors for sample groupings, differences between multi- and monocentric mice often encountered in preclinical randomized trials must be recognized