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The primary outcome focusing on changes in motor and non-motor symptoms over a 12-month period

In one clinical trial on Wegovy, the average weight loss was 15% in 68 weeks

These underlying hormonal issues continuously counteract the positive effects of the GLP-1 medication, leading directly to reduced effectiveness and frustration consistently

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The research team found that participants with genetic makeup mimicking the effect of GLP-1 receptor agonists leads to reductions in both lean mass (whole-body fat-free mass and trunk fat-free mass) and body fat (whole-body fat mass, trunk fat percentage and body fat percentage)