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The relevance to GLP-1 patients: the Paschou 2025 review identified reduced cellular ATP production as one of the proposed mechanisms by which GLP-1 medications may affect skin

Response: We appreciate the feedback on additional measures and elements to improve the quality of care for heart failure patients, such as those focused on early screening and diagnosis of CRM conditions, palliative care, CAHPS patient experience measures, depression screening, novel medical therapies, and composite guideline-directed medical therapy (GDMT)

PMC 3134129

Studies like this provide important information regarding how brain chemistry may change in response to disease and to therapeutic intervention, Dr