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A Shimadzu LC20AD, Ultra Performance Liquid Chromatography (UPLC) system (Shimadzu Corporation, Kyoto, Japan) equipped with Shimadzu 8040 triple quadrupole (QqQ) mass analyzer (Shimadzu Corporation, Kyoto, Japan) with an electrospray ionization source (ESI) operated in the positive charge mode for the quantification of 2

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doi: 10.1038/s41429-021-00436-z 78 GottwaldEMDussMBugarskiMHaenniDSchuhCDLandauEMet al

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Structurally, it comprises three primary functional groups: (i) two aromatic ring systems with an alpha, beta-unsaturated beta-diketone moiety, (ii) one o-methoxy phenolic group, and (iii) a seven-carbon linker (74)