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Supernatants were filtered over 0.2 m filters and stored at -20C until analysis
We visualized single-cell data via principal component analysis (PCA) considering only the expression of proteins associated with cellular metabolism (GLUT1, HK, GAPDH, LDHA, G6PD, CD98, CS, ATP5A, CD36, CPT1A, ACADM, ACLY, FASN, SCD1, LAL, mTOR, pAKT, pS6, AMPK), and determined that CAR T cells from STR and LTR have distinct metabolic states (Fig
These injections are favored over oral supplements since the digestive system can break down glutathione, leading to reduced bioavailability when taken by mouth
Our TRT overview page walks through how the two programs interact and what follow-up looks like