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They can include redness, slight swelling, mild soreness, or itching

Phase 2 trial data showed retatrutide was generally well-tolerated, with a safety profile similar to other GLP-1 medications (semaglutide, tirzepatide)

In the review youll also find practical details that help other readers decide if its worth exploring: how the reviewer titrated doses slowly to manage nausea, how they scheduled weekly injections to fit their routine, and how they coordinated lab monitoring with their primary care provider

In the first sensitivity analysis comparing the risk of incident NAION in persons with T2D treated with SGLT2 inhibitors alone ( n = 40,206, reference), once-weekly semaglutide alone ( n = 71,658), and once-weekly semaglutide and SGLT2 inhibitors combined ( n = 45,401), we observed 6 events in 82,877 person-years, 36 events in 178,868 person-years, and 31 events in 119,106 person-years, respectively, corresponding to adjusted HR of 242 (95% CI 097 606) and 262 (95% CI 102674) for once-weekly semaglutide without and with SGLT2 inhibitors in a multivariable model adjusted for sex, age, marital status, duration of diabetes, hemoglobin A1c, estimated glomerular filtration rate, cardiovascular disease, use of insulin, use of cholesterol-lowering medicine, and use of blood pressure lowering medicine

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