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Sold as a food supplement under UK food supplement legislation, not regulated by the MHRA as a pharmaceutical product no pre-market proof of efficacy or safety is required

For example, in a 2021 randomized, controlled trial, 100-200mg of dihydroberberine yielded higher blood levels of berberine than 500mg of the standard stuff

Xotch, the Xenopus homolog of Drosophila notch

A study in the International Journal of Dermatology revealed that combining oral PLE with sunscreen achieved a greater reduction in melasma severity than sunscreen alone

The items were very relevant to the topic, and the survey respondents were a sample of the same group of people for whom the study results are most relevant