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Dose definitions followed original RCT classifications [19,20,21, 47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65]: canagliflozin (low: 100 mg, and high: 300 mg)

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This flow of electrons is coupled to the pumping of protons by complexes I, III, and IV across the inner membrane and into the inner mitochondrial membrane space, generating a proton gradient

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