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All oligos were resuspended in TE buffer at a concentration of 500 M

Upon activation by GLP-1RAs, GLP-1R initiates diverse intracellular cascades, such as the cyclic adenosine monophosphate (cAMP) / protein kinase A (PKA) pathway and phosphatidylinositol 3-kinase (PI3K) / protein kinase B (Akt) signaling pathway [1, 9]

Originally marketed as a treatment for Type 2 diabetes, they have also been used for weight loss for those who can afford them

These medicines improve health through reduction of blood glucose and body weight, by attenuation of inflammation and via direct activation of receptors in target tissues

Cardiovascular safety in terms of MACE risk reduction, which is always a concern in T2DM, is well established for the monocomponents [32,33,34,35]