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Solving the structure of this protein alone or with its substrate will help in designing better inhibitors of this enzyme
Some DNA methylation in the promoter regions of specific genes related to lipid metabolism (PPARG, PPARA), 212 low-density lipoprotein receptor-related protein 1 (LRP1), 213 lipoprotein lipase (LPL), 214 SREBF1/2, 215 and inflammation (stearoyl-CoA desaturase 1 (SCD1), chemokine C-C motif chemokine ligand 2 (CCL2), TNF-, and TGF-1) 216,217 are associated with adipose tissue dysfunction and could lead to metabolic disorders
Interestingly, these inhibitory effects appeared to be mediated by a blocking action on membrane binding activity, indicating that betalains target cell signalling pathways at the molecular level, acting in a similar fashion to selective COX-2 inhibitor drugs [26,70]
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