Cardiovascular diseases (CVDs) are the prime cause of morbidity and mortality worldwide (Roth et al., 2020)
Sublingual administration, offering a balance of efficacy, accessibility, and compliance, emerges as a promising approach for routine clinical use
Skin Repair: Alpha lipoic acid also assists in skin repair by aiding in cell turnover and renewal, helping to heal damaged skin and reveal a fresher, smoother texture
Clinical data from the SURMOUNT trials demonstrated that tirzepatide delivers weight reductions between 20-21% at the highest therapeutic dose, significantly outperforming older GLP-1-only treatments
Translational studies using exosomes showed a relationship between the epigenetic modulation of glutamatergic function and a brain metabolic dysfunction known as insulin resistance (IR) as showed by an increase and sex-specific phosphorylation in the expression of IRS1, a key marker of the insulin signaling cascade, in discrete exosomes enriched for the neural cell adhesion molecule L1 (L1CAM), a protein highly expressed in the brain [52, 70,71,72]
