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White, A., et al., Reduced glucose-stimulated insulin secretion following a 1-wk IGF-1 infusion in late gestation fetal sheep is due to an intrinsic islet defect

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IGF 1 LR3 vs

These modifications significantly reduce binding affinity for IGF binding proteins (IGFBPs 1 through 6), extending functional availability in in vitro assay systems

This potential has been evaluated in cell growth studies, throughout which researchers first prompted the need for developing this high-potency variant