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CagriSema produces higher rates of nausea (55% versus 31%) and vomiting (26% versus 12%) compared to tirzepatide in their respective clinical trials

For example, semaglutide (Wegovy) can be used as a treatment for Type 2 diabetes alongside being a licensed weight loss drug

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Treatment of human and mouse small intestine organoid models with SCFAs increases the number of GLP-1-producing cells twofold 284 , and SCFA infusion activates colonic EECs to increase GLP-1 release in mice 281