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10.1053/j.gastro.2012.06.031 199

When elevated, there was increased fat accumulation, reduced metabolic efficiency, and mitochondrial dysfunction

Sasu et al., 2010)

It is a component of two essential cofactors used by numerous cellular enzymes, including methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate and homocysteine metabolism