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The high state in PMW is seen after excessive withdrawal of systemic estrogenic hormones, which deeply affects the physiological process and disrupts the gut milieu and integrity (244)

Acknowledgments We acknowledge the support from the Department of Developmental Cell Biology, Cell Biology Division, Key Laboratory of Cell Biology, Ministry of Public Health, Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University

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If this happens, throw the needle in a sharps container and start over