glp 1 drugs wikipedia Can one drug do it all? Reviewing the expanding clinical universe of GLP-1 agonists Mapping the effectiveness and risks

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systematic review of 13 Table 1 GLP-1 receptor agonistspharmacokinetic properties and clinical characteristics Agent Half-life Dosing schedule Peak concentration Bioavailability Duration of gastric eects Semaglutide 7days (165184h) Once weekly 13days 89% May persist 12weeks Liraglutide 13h Once daily 812h 55% 2448h Exenatide IR 2.4h Twice daily 2.1h Variable 2448h Exenatide ER ~ 2weeks Once weekly Multiphasic Variable 12weeks Dulaglutide 5days Once weekly 24weeks Variable 12weeks Tirzepatide 5days Once weekly 45weeks Variable Potentially reduced Content courtesy of Springer Nature, terms of use apply

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