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The protolerogenic effect of A1AT is evident on dendritic cells (DCs): these cells, at the interface between innate and adaptive immunity, are responsible for antigen presentation to T lymphocytes and priming of naive T cells

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It was therefore concluded that NiCl 2 induces p38 MAPK-dependent lytic cell death and stimulates markers of premature eryptosis, which may explain the changes in hematological parameters observed in poisoning victims [420]

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