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Effectiveness: What the Research Shows GLP-1 receptor agonists GLP-1 receptor agonists have been tested across large clinical programs

Other drugs, such as monoamine oxidase B (MAO-B) inhibitors (e.g., rasagiline, safinamide, selegiline) or catechol-O-methyltransferase (COMT) inhibitors (e.g., entacapone, tolcapone), may also be used to improve dopamine levels, although sometimes symptoms may persist or worsen even with optimized dopaminergic therapy (Pardo-Moreno et al., 2023

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