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Prostaglandin D2 Generation from Human Lung Mast Cells Is Catalysed Exclusively by Cyclooxygenase-1. European Journal of Pharmacology, vol

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A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR