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While this study did not include metformin as background therapy, it established tirzepatide's independent weight loss efficacy (up to 22.5% body weight reduction with the 15 mg dose at 72 weeks)
The estimated hazard ratio for time to first MACE was 0.86 (95% CI: 0.77, 0.96) over the median follow-up duration of 49.6 months and 49.4 months for patients randomized to RYBELSUS and placebo, respectively
Comparing 15 mg to other tirzepatide dose levels Seeing how 15 mg stacks up against lower doses provides useful context for understanding where you sit in the dosing landscape and what changes you can expect compared to your previous dose level
While both are powerful tools for metabolic health, they work in slightly different ways to quiet "food noise" and improve hormonal balance
Some evidence suggests other GLP-1s, specifically liraglutide or exenatide, may also influence other hormones, such as testosterone, growth hormone, and luteinising hormone in the short-term
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