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Urick ME, Bell DW

Complementary for ischemic conditions (retinal vein occlusion, non-proliferative diabetic retinopathy) where revascularization beneficial versus proliferative diseases requiring anti-VEGF

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Despite structural similarities to AA-derived eicosanoids, some EPA-derived eicosanoids are potent anti-inflammatory and anti-nociceptive agents

Generally, there is an untargeted discovery process involving control and dosed samples from nonclinical or clinical studies (Amacher 2010)