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In an additional scenario, reduced ERK1/2 and MAPK activity hindered muscle glucose transport and caused insulin resistance (IR) [42]

As shown by electron microscopy, large numbers of mononuclear cells with pigment granules are observed in the mucosa of MC, an observation that can be divided into 4 histological grades24 (Table 1)

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The findings demonstrate that the dosage of H 2 O 2 causes a rise in mitochondrial calcium while having no effect on the cytoplasmic calcium ( Importantly, the production of ROS is crucial to understanding the overall effect of ROS generation on endoplasmic reticulum stress