[] In a 15-year-old girl with unresponsive to treatment OCD, the addition of NAC (adjusted from 600 mg daily to 2.4 g/day for 6 weeks and continued for another 18 weeks at 2.4 g) to citalopram considerably reduced the severity of OCD symptoms, according to Yazici and Percinel (2014)
This situation would lead to a self-perpetuating cycle, in which the free radicals generated would induce GSH depletion, thus increasing oxidative stress that would reduce antioxidant enzyme levels, which would further reduce GSH synthesis
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An enzyme called Carnitine Palmitoyltransferase I (CPT1), located on the outer mitochondrial membrane, attaches a molecule of L-carnitine to the long-chain fatty acid, creating an acylcarnitine complex