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Avoid caffeinated, sugary, and alcoholic beverages, as they can exacerbate symptoms

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In the SEMALEAN study from 2025, semaglutide treatment led to a 15% reduction in total body fat mass

Overall, IGF-1R mAbs hold promise for prostatic cancer treatment, but further research is needed to optimize their efficacy and safety, particularly in combination therapies, while exploring new mAbs with improved targeting strategies

Comment: Several commenters expressed concerns with the methodology CMS uses to identify topped-out measures in specialty measure sets and MVPs as at risk and, therefore, eligible for the defined topped-out measure benchmark