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Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

Clinical takeaway Before concluding that a peptide failed, verify the diagnosis and identify the primary driver

The same is true for fatigue that rest doesnt fix, mood changes that feel out of character, hot flashes that intensify after starting treatment, and a notable drop in libido

furthermore, 60-70% of patients stop treatment within the first 12 months

Medicare Part B claims are billed with 67028-50 on one line, fees doubled, and 1 unit