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Informed consent The study presented in this article did not require human experimentation

Notably, cotadutide also alleviated fibrosis to a greater extent than liraglutide or obeticholic acid, despite dose adjustment to achieve similar weight loss in two preclinical mouse models of NASH

They provide CH groups required for phosphatidylcholine synthesis, which is the phospholipid that coats VLDL particles and allows them to transport triglycerides out of hepatocytes

Within the CNS, these receptors are predominantly expressed in brain regions involved in processing rewards, including the ventral tegmental area (VTA) and nucleus accumbens (NAc) (Marty et al ., Reference Marty, Farokhnia, Munier, Mulpuri, Leggio and Spigelman2020)