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They also decline with metabolic stress, obesity, and high-fat diets

Patients should be monitored for signs of dehydration, electrolyte abnormalities, and nutritional deficiencies, particularly if gastrointestinal side effects limit intake

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Thomas FC, Taskar K, Rudraraju V, Goda S, Thorsheim HR, Gaasch JA, Mittapalli RK, Palmieri D, Steeg PS et al (2009) Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer

2,7-dichlorofluorescin-diacetate (DCFDA) was used for reactive oxygen species (ROS) measurement