Your large intestine absorbs water and minerals, which are then transported to the liver to be processed and detoxified
NAD+ for cellular energy
The following are known triggers of mast cell degranulation (in addition to IgG activation via pathogen or allergen):[ref] Acetylcholine Complement fragments (C3, C4, C5) Various drugs, environmental toxins (MRGPRX2 receptor, details below) Peptides (including endorphin, leptin, PTH, and more) Physical conditions (cold, heat, pressure, stress, and vibration)
If fatigue is severe, sudden, or unexplained, bring it to your clinician B12 is one possible factor, but it's not the only one worth ruling out
B12 Cyanobalamin Cyanocobalamin is a synthetic form of vitamin B12 used to prevent and treat vitamin B12 deficiency