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The upregulation of SLC7A11 in glioblastoma (GBM) leads to heightened levels of extracellular glutamate, facilitating the proliferation, activation, and suppressive capabilities of regulatory T (Treg) cells, consequently fostering intratumoral immunosuppression (49)

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Side effects in trials included water retention, increased appetite, and mild fasting glucose elevation, consistent with sustained GH secretagogue activity

J Virol (2015) 89(1):61525

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