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However, Sandoz plans to launch a generic version of semaglutide (the active ingredient in Ozempic and Wegovy) in Canada in 2026, following the expiration of Novo Nordisks patent

For Novo Nordisk, Wegovy holds 16.5% of the market, Rybelsus 6.0% , Saxenda 1.6% , and Victoza 1.1%

In contrast, in murine models Glp1r mRNA transcripts are predominantly found in isolated atrial cardiomyocytes, with no expression detected in ventricular cardiomyocytes (47)

Multiple glutamate-targeted antidepressants are actively in development, and two are approved

1 Proposed regulatory mechanisms between silent mating type information regulation 2 homolog (SIRT1) and AMP-activated protein kinase (AMPK)