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Even though developing a vaccine against GPNMB positive cells seems to be beneficial, the challenge remains to only deplete cells with the highest expression of the protein but not the cells expressing it at a physiological level 63

Furthermore, the peptide ApoE-DBCO, capable of specifically binding to LDLR expressed on brain endothelial cells and glioma cells, was coupled to the azido group of nanoprobe through a Cu-free click cycloaddition reaction

[] They were used in traditional medicine in China and India and demonstrated specific toxicity toward PCa when investigated in cell culture

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Dixit V, Pandey V, Shyam R