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In rare cases, glutathione supplementation can cause unpleasant side effects

Potential causes include depression, stress, untreated sleep apnea, delirium, side effects of medications, Lyme disease, thyroid problems, head injury, blood clots or tumors in the brain, certain vitamin deficiencies and excessive alcohol consumption

doi: 10.1038/s41580-020-00324-8 72 KaganVEMaoGQuFAngeliJPFDollSCroixCSet al

Detoxification Challenges: Reduced glutathione levels can hinder the body's ability to effectively detoxify harmful substances, potentially leading to an accumulation of toxins

Unwanted facial hair growth (hypertrichosis) occurs more frequently in women, even with proper application technique, resulting from systemic absorption affecting facial follicles