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Para la dieta normocalrica se us alimento concentrado para ratones (ratarina), suministrado ad libitum y con libre acceso al agua

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However, its effects vary across specific cognitive dimensions, including executive function and memory

Participants randomized to retatrutide initiated treatment with 2 mg once weekly and increased the dose in a step-wise approach every four weeks until reaching the target dose of 9 mg (via steps at 2 mg, 4 mg and 6 mg) or 12 mg (via steps at 2 mg, 4 mg, 6 mg and 9 mg)

a P-values from a repeated measures ANOVA on mean home glucose levels change from baseline with treatment, insulin use (Yes/No), Week (1 to 12), Time of day (Breakfast, Lunch, Dinner and Bedtime), and center as factors and subject as random effect