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Dual agonism with GLP-1 and amylin As WL with GLP-1 RA and amylin analogues results both from distinct and overlapping pathways, a combination of these entero-pancreatic hormones may induce a synergistic WL effect [84]

Lancet Oncol 16(1):108116 Kraemer WJ, Ratamess NA, Nindl BC (2017) Recovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise

While semaglutide has not been studied in a dedicated OSA trial of this scale, the weight loss it produces likely offers similar benefits, since the primary mechanism is fat reduction around the airway and abdomen

CT-388 (enicepatide), a dual GLP-1/GIP injectable, delivered 22.5% weight loss in Phase 2 with 54% of patients on the highest dose achieving a BMI under 30

However, the specific changes in the immune microenvironment remain unclear